Study uncovers potential therapeutic targets for low platelet blood disorders
Thrombocytopenia is a blood disorder characterized by low levels of blood platelets. These tiny blood cells, which help with clotting, are made in the bone marrow and spleen by cells called megakaryocytes. However, little is known about the regulatory factors involved in platelet formation, which could be used to develop more effective therapeutic strategies for thrombocytopenia. MLL3 and MLL4 are part of a protein complex that modifies...
Chemotherapy drives changes to the genome and clonal architecture of blood stem cells that may increase risk of secondary malignancies
Hematopoietic stem and progenitor cells (HSPCs) – a main source of blood cell production – can accumulate DNA mutations over time, which can...
Presurgical radiation therapy may offer alternative approach to treating brain metastases
Many patients with brain metastases receive stereotactic radiation therapy (SRT) – a targeted high dose of radiation – after surgery to remove...
Injectable immunotherapy yields high remission rates in patients with B-cell ALL
Some patients with relapsed or treatment-resistant B-cell acute lymphoblastic leukemia (B-ALL) are unable to receive chemotherapy and have limited alternative treatment options. Blinatumomab is a type of immunotherapy that simultaneously engages T cells and leukemia cells to eliminate the cancer cells. The treatment currently is approved as a continuous infusion over 28 days, though a subcutaneous injection would offer a simpler administration...
Triplet combinations improve outcomes for elderly patients with IDH-mutant AML
New targeted therapies have improved treatment options for elderly patients with IDH-mutant acute myeloid leukemia (AML) who are not eligible...
Biomarker in pancreatic cysts could predict risk of cancer progression
Pancreatic cysts are fluid-filled growths that appear on or in the pancreas and have the potential to develop into pancreatic cancer...
Heated chemotherapy improves overall survival in some patients with colorectal cancer
Some patients with advanced colorectal cancer develop metastases in the lining of the abdominal cavity, known as peritoneal metastases...
Researchers identify driver of nervous system overactivity in hypertension
The hypothalamus is an area of the brain that controls the sympathetic nervous system – which regulates the fight or flight response – by...
Researchers identify novel target for high-risk multiple myeloma
High-risk multiple myeloma is an aggressive disease in which plasma cells grow  uncontrollably. It is typically resistant to treatment...
Targeting cells that form blood vessels in glioblastoma could improve treatment
The formation of new, small blood vessels – known as microvascular proliferation (MVP) – is a hallmark of glioblastoma, the most common and...
Researchers identify CREM as a critical regulator of CAR NK cell function
Chimeric antigen receptor (CAR) natural killer (NK) cells represent a promising experimental cell therapy, but the molecular mechanism regulating...
Study uncovers novel role for BRCA2, suggesting new therapeutic strategies
BRCA2, a key tumor suppressor that helps repair and protect DNA during replication, is often mutated in cancer cells. Normally, BRCA2 interacts...
Pre-surgical combination therapy shows promising results for NSCLC
Chemotherapy and immunotherapy combined with surgery is the standard treatment for patients with early-stage resectable non-small cell lung...
Study identifies a new driver and therapeutic vulnerability of bone metastasis
One of the most common sites for cancer to metastasize is the bone. Unfortunately, patients with bone metastases have a poor prognosis and...
Study uncovers epigenetic driver of bone metastasis in advanced prostate cancer
Nearly 80% of men with advanced prostate cancer develop bone metastases, leading to bone pain, fractures and a poor prognosis. Using laboratory...
Antibody treatment is safe for elderly patients with relapsed/refractory multiple myeloma
Treatment with teclistamab, a bispecific antibody, was recently approved for patients with relapsed/refractory multiple myeloma (RRMM) based...
Biomarker-guided combination therapy targets subtype of advanced prostate cancer
Castration-resistant prostate cancer (CRPC) remains one of the most lethal and treatment-resistant forms of prostate cancer, highlighting...
Sickle cell disease changes DNA structure of cells to suppress immunity
Sickle cell disease changes DNA structure of cells to suppress immunity
Patients with sickle cell disease, an inherited disorder that...
Mapping changes in lung precancer reveals TIM-3 as potential intervention target
Lung cancer is often diagnosed at late stages, making treatment challenging. To understand its early development, researchers led...
Self-advocacy may lead to less pain in older breast cancer survivors
Many older female breast cancer survivors experience persistent pain, but they are unsure how to gauge pain intensity and often have anxiety...
Novel combination provides more effective treatment option for mantle cell lymphoma
The latest treatment for mantle cell lymphoma (MCL) – an aggressive and incurable B-cell lymphoma – includes Bruton tyrosine kinase (BTK)...
Activating leukemia stem cells makes chemotherapy more effective in AML
Acute myeloid leukemia (AML)Â is a hard-to-treat cancer in which certain leukemia stem/progenitor cells (LSPCs) hide in the bone marrow...
Study identifies potential biomarker for treatment response in glioblastoma
Glioblastoma, the most common type of central nervous system tumor, is generally resistant to immune checkpoint blockade, highlighting a need...
Comprehensive spatial map provides insights into pancreatic cancer metastases
Pancreatic cancer is notoriously difficult to treat, resulting in a five-year survival rate of roughly 12%. Approximately half of patients...
Triplet regimen is well tolerated by patients with AML but does not improve survival outcomes
Patients with acute myeloid leukemia (AML)Â who have high-risk genetic changes and those with relapsed disease have poor outcomes with...
Gut microbiome impacts CAR T cell therapy responses, side effects in multiple myeloma
The gut microbiome has been linked to chimeric antigen receptor (CAR) T cell therapy response and related toxicities, but few researchers...
Pilot nursing study explores physical activity during and after hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) is a vital treatment for blood cancers, but it is also an intense therapy with lengthy hospital...
CLL-derived exosomes alter body’s immune and hematopoietic systems in CLL patients
Immunosuppression, neutropenia and anemia can occur in patients with chronic lymphocytic leukemia (CLL) – a type of blood cancer that disrupts...
Agents that cause ‘copper overload’ can overcome radiotherapy resistance in preclinical models
Radiation therapy, or radiotherapy, can successfully treat multiple cancers, but some patients develop resistance to this treatment, known...
Novel blood-based biomarker identified in newly diagnosed acute myeloid leukemia
Inflammation in patients with acute myeloid leukemia (AML) can impact responses to certain treatments, underscoring a need for better methods...
Landmark study maps spatial organization of cancer-associated fibroblasts across cancers
Landmark study maps spatial organization of cancer-associated fibroblasts across cancers
Cancer-associated fibroblasts (CAFs) are essential...
Combination therapy shows no added survival benefit in patients with cervical cancer
Patients with intermediate-risk cervical cancer often receive chemotherapy with radiation therapy after surgery, but the added benefit of...
BCMA-directed CAR T cell therapy is safe in patients with relapsed or refractory multiple myeloma and CNS involvement
Due to the risk of associated neurotoxicities, some clinicians are hesitant to consider B-cell maturation antigen (BCMA)-directed chimeric...
Whole-slide imaging allows real-time remote diagnosis for breast cancer
Pathologists traditionally use light microscopy to evaluate stained frozen sections of lymph nodes obtained during surgery in patients...
Study provides genomic insights into treatment resistance in SMARCA4-mutant lung cancer
SMARCA4 – a gene that helps in chromatin remodeling – frequently is mutated in lung cancer, leading to immunotherapy resistance and a...
Phase II study identifies potential biomarkers in HPV-positive anal cancer
Cytotoxic chemotherapy is the standard of care for patients with unresectable and metastatic squamous cell carcinoma of the anal canal – a...
Bioinformatics chatbot can analyze large-scale cancer proteomics data
Comprehensive cancer omics initiatives like The Cancer Genome Atlas (TCGA) provide a wealth of DNA and RNA data, but little is known about...
Combination therapy yields strong long-term overall response rate in newly diagnosed acute myeloid leukemia patients
Intensive chemotherapy remains the standard treatment option for medically fit patients with newly diagnosed acute myeloid leukemia (AML)....
Study offers insights into evolutionary process driving pancreatic cancer aggressiveness
Pancreatic cancer is hard to treat because of its heterogeneity, a characteristic frequently sustained by the ability of cells to change states...
Researchers identify epigenetic biomarker for breast cancer metastatic relapse
Cancer cells that initiate metastasis at secondary sites often enter a dormant state, allowing them to evade treatment and later reawaken...
Surgery enhances immunotherapy in advanced kidney cancer
Patients with advanced solid tumors are usually ineligible for surgery. However, surgically removing the primary tumor in preclinical models...